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Vidalista contains the active ingredient tadalafil. This medicine works by increasing blood flow to the male genital organ penis, which helps to produce the ideal erection when accompanied with sexual stimulation. Take this drug exactly as prescribed by your doctor, including the recommended dosage and duration. This drug is safe to use with or without food. Other drugs are usually administered on demand, 30 to 60 minutes before sexual activity. Tadalafil substitutes work for up to 4 hours. If taken orally, tadalafil can be effective for up to 36 hours. When a man is sexually stimulated, his body naturally increases blood flow to his penis in order to produce an erection.